After leaving the airport follow the sign for Trogir direction(RIGHT TURN) drive straight ahead.
When entering Trogir follow the sign for Seget Donji (also keep driving straight ahead).
When driving through Seget Donji look out for signs on the left for Hotel Jadran and Villa Kairos as you go up a hill out of the village.
100m after Villa Kairos, you will see a sign on the right for Hotel Medena. Take the next sharp left turn, just before a sign on the left for Villa Kostovic. You will go down a small road past Apartments Julio.
The last house on the right is Villa Irena, with garages on the left and a covered parking area on the right.
If you reach the Hotel Medena you have gone too far. Turn round in the hotel grounds, take the road out of the complex up the hill towards Trogir and Split, go onto the main road, past a small side road to a restaurant and take the next right slip road. This leads down to Villa Irena.